gastrointestinal activity gastrointestinal function
Conditions
Interventions
-Ingestion of a multisugar and glutamin/alanin solution
-Exercise with different load
Ergometertest
Gastro-intestinal activity
Healthy men
Interlaboratory evaluation
Sponsors
Hogeschool Utrecht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: -Male -Generally healthy -Recreational athlete with at least two years of cycling experience of at least twice a week -18-35 years old -Meeting criteria of valid max-test -Body mass index (BMI) 18.5-25 kg/m2 -Veins suitable for blood sampling at inspection
Exclusion criteria
Exclusion criteria: -Diagnosed with an immune disease such as diabetes, coeliac disease, rheumatoid arthritis -Diagnosed with an gastro-intestinal disease such as Crohn*s disease, colitis ulcerosa, irritable bowel syndrome -abnormal ECG, e.g. an aberrant QT time -Allergies -Smoking -Use of hard drugs -Use of pre- and probiotics -(Chronic) use of specific medicines: *chronic use of NSAIDs: aspirin, ibuprofen, corticosteroids *chronic use of antidepressiva, antacids (Rennie), benzodiazepines (Valium) * drugs against abdominal pain and cramping (e.g.buscopan, imodium), -Participation in other scientific studies within 1 month before the preliminary testing -Blood donation six weeks prior to the start of the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The relative changes in blood of iFABP (intestinal function), lymphocytes, leukocytes, monocytes (immune response). | — |
Secondary
| Measure | Time frame |
|---|---|
| The relative changes in blood, urine and saliva of several markers of intestinal function, immune responsiveness and general physiology: e.g. cytokines, RNA-profiling of bloodcells, cortisol, aminoacids, sugars. | — |
Countries
The Netherlands
Outcome results
None listed