The effect of haemoadsorption in relation to the cytokine concentration during cardiothoracic surgery procedures while using extracorporeal circulation.

The effect of haemoadsorption in relation to the cytokine concentration during cardiothoracic surgery procedures while using extracorporeal circulation. - CS-Study (Cytosorb study)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON45517

Enrollment

Registered

2017-03-15

Start date

2017-06-05

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Produktie van cytokine door het lichaam tijdens open hartchirurgie. Cytokine production Inflammatory reactions

Interventions

The intervention consists of the leading blood through the Cytosorb adsorber during CABG-surgery.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Elective CABG Signed informed consend age >18 years,

Exclusion criteria

Exclusion criteria: Emergency surgery Combined surgical intervention Coagulation disorders Low platelet count 5 mg/l Patients that are Heparin Induced Thrombocytopenia (HIT) positive and citrate regional anticoagulation is unavailable as an alternative anticoagulation method. Hypersensitive / allergic reaction to: polystyreen/divinylbenzeen, polycarbonaat, polypropyleen, siliconen en polyester

Design outcomes

Primary

Measure	Time frame
To analyze of the haemoadsorption device Ctosorb. We will evaluate whether the elevated cytokine levels (IL-6, IL-8, IL-10 and TNF-alpha) as a result of surgery can be reduced to the initial value. This will be done during elective CABG procedures with the use of ECC.	—

Secondary

Measure	Time frame
None.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)