lack of postoperative peristalsis postoperative ileus
Conditions
Interventions
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - elective laparoscopic hemi- or partial colectomy with an anastomosis for colorectal carcinoma or elective laparoscopic liver resection for benign or oncological indication - >18 years of age - signed informed consent
Exclusion criteria
Exclusion criteria: - pre-existing immune deficiency - use of immunosuppressant drugs - previous colorectal resection or (chemo)radiation - previous major liver surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Absolute cell numbers of different leukocyte populations in peripheral blood. The studied populations will consist of T-cells (both CD4+ and CD8+), B-cells, NK-cells, Neutrophils, Eosinophils, Basophils and monocytes. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Comparison of leukocyte subset kinetics between patients that got a (prolonged) postoperative ileus and those that didn*t after elective laparoscopic hemi- or partial colectomy for malignancy. - First bowel sound, tolerance of oral food intake, passage of defecation and passage of flatus after surgery - Postoperative opioid consumption - Patient characteristics: Date of birth, date of operation, age, sex, length, weight, BMI, ASA-score, diabetes mellitus, smoking status, alcohol abuse, preoperative medication use (antihypertensiva, antihypercholestrolemia, corticosteroids, anticoagulants, NSAID*s), cardiac history, cardiac symptoms, peripheral arterial disease, pulmonary history, pulmonary symptoms, preoperative ileus, neoadjuvant radiotherapy, neoadjuvant chemo-radiation, bowel preparation, prophylactic antibiotics. - Surgical characteristics: Type of surgery, anastomosis (type, primary, configuration, location, stapled/hand-sewed, omentoplasty), operation indication, operation time, anaesthesia, intra-operative complications, blood loss, date of admission, date of discharge, duration of hospitalization, drain (place, type), stoma (place, type), donuts, air-leaking test (including outcome), surgeons (amount and expertise) and postoperative complications. | — |
Countries
The Netherlands
Outcome results
None listed