Hypertension
Conditions
Interventions
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients with hypertension: • 18 years and older • Hypertension >140/90 mm Hg at inclusion. • Patients must be part of the *zorgpad hypertensie*. These patients are temporary drug naïve and are switched on to medication after two weeks of being drug naïve as part of this *zorgpad hypertensie*.;Inclusion criteria for healthy volunteers: • 18 years and older
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients with hypertension: • Impossibility to undergo MRI (claustrophobia, implants or metal objects in or around the body) • Pregnancy • Non-Dutch speaking • Illiterate;Exclusion criteria for healthy volunteers: • Impossibility to undergo MRI (claustrophobia, implants or metal objects in or around the body) • Pregnancy • Treated with antihypertensive medication • Non-Dutch speaking • illiterate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are the structural and functional MRI differences between baseline and follow-up scans (both 3T and 7T MRI). | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study parameters are the structural and functional MRI differences between patients and healthy volunteers. The tertiary study parameters are the difference between morning and evening total brain volumes, CSF volumes, and perfusion status as measured with 3T MRI. The quaternary study parameter/endpoint is the clinical consequences of hypertension as measured with neuropsychological tests. | — |
Countries
The Netherlands
Outcome results
None listed