Impact of galacto-oligosaccharides on microbial fermentation capacity and markers of frailty in adults and elderly

Impact of galacto-oligosaccharides on microbial fermentation capacity and markers of frailty in adults and elderly - GOS and microbial fermentation in aging

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON45484

Enrollment

Registered

2017-03-01

Start date

2017-03-29

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastrointestinal symptoms

Interventions

Subjects will be randomized into one of the two intervention periods. One period subjects will receive 7.24 grams of Vivinal GOS supplements three times daily for four weeks. In the other period, su

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: No gastrointestinal complaints Age between 25-50 years (and robust by citeria of Fried et al. 2001) and 70-85 years (and prefrail by criteria of Fried et al. 2001) BMI between 20 and 30 kg/m2

Exclusion criteria

Exclusion criteria: Use of antibiotics in the 90 days prior to the study Use of laxatives within 14 days prior to the study Pregnancy Administration of probiotic or prebiotic supplements in the 14 days prior to the study

Design outcomes

Primary

Measure	Time frame
Microbial composition and activity	—

Secondary

Measure	Time frame
Innate immune signaling and defence Metabolite production Digestive parameters / side effects	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)