cardiac function
Conditions
Interventions
To induce the changes in afterload we will use two different interventions:
- To reduce the afterload (and preload) we will use vasodilative medication
(vasodilator
nitroglycerine), which will primary reduce the peripheral
vascular resistance.
- To increase the afterload we will use anti gravity jeans to occlude the blood
supply of the legs for 2 minutes (trans
Cardiac function
Echocardiography
Hemodynamics
Strain-volume loop
Sponsors
Fysiologie
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Age (between 18 and 30 or above 60) voluntary participation
Exclusion criteria
Exclusion criteria: History of cardiovascular diseases (coronary disease, hypertension, collapse, cardiac failure, peripheral vascular disease) Diabetes mellitus Use of medication that influences the cardiovascular system Contraindication to use nitroglycerin (hypersensitivity or usage of medication that interacts wit nitroglycerin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study parameter will be the slope of the systolic strain-volume relation (Sslope) | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary parameters will be the early systolic strain (*_ES), peak strain (peak *) and the dissociation between the systolic and diastolic strain-volume relation during early diastole (UNCOUP_ED) and late diastole (UNCOUP_LD). | — |
Countries
The Netherlands
Outcome results
None listed