VLDL1, VLDL2, and LDL apolipoprotein B-100 kinetics in patients with familial hypercholesterolemia of unknown origin (FH4)

VLDL1, VLDL2, and LDL apolipoprotein B-100 kinetics in patients with familial hypercholesterolemia of unknown origin (FH4) - APPRECIATION

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON45448

Enrollment

Registered

2017-03-31

Start date

2017-05-22

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Familial hypercholesterolemia

Interventions

n.v.t.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Diagnosis of familial hypercholesterolemia of unknown origin (FH4) based on Dutch Lipid Clinic Network criteria (Nordestgaard et al. 2013) and negative DNA-testing (mutations in LDLR, ApoB, PCSK9). - Untreated LDL-cholesterol levels of > 95th percentile for affected members - 18-65 years of age;Controls: - Unaffected family member with untreated LDL-cholesterol between 20-60th percentile - 18-65 years of age Or: - Persons with mutations in LDLR, APOB, or PCSK9 gene or other genes involved in lipid metabolism. - 18-65 years of age

Exclusion criteria

Exclusion criteria: · Heavy alcohol use · Dysthyroidism · Pregnancy, breastfeeding · Renal insufficiency (creatinine >150 µmol/L) · Diabetes mellitus

Design outcomes

Primary

Measure	Time frame
Tracer/tracee ratio, pool size, fractional catabolic rate, and production rate in FH4 subjects compared with (family) controls and/or dyslipidemic patients with mutations in established lipid genes.	—

Secondary

Measure	Time frame
n.v.t.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)