AMC colorectal organoids biobank: a living biobank

AMC colorectal organoids biobank: a living biobank - Living CRC biobank

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON45427

Enrollment

200

Registered

2017-03-08

Start date

2017-03-30

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colorectal cancer Colorectal carcinoma

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1) (pre-stage) colorectal carcinoma 2) age of 18 or higher 3) scheduled for resection or colonoscopy 4) written informed consent for study participation

Exclusion criteria

Exclusion criteria: None

Design outcomes

Primary

Measure	Time frame
Primary research question is to evaluate the association and predictive value of sensitivity or resistance to chemotherapy of established primary human organoids and the response of patients to the same chemotherapy. In other words, what is the correlation between non-responsiveness of the organoids to a specific compound and recurrence of the disease in adjuvantly treated patients.	—

Secondary

Measure	Time frame
Secondary research questions include 1) association between non-responsiveness of the primary cultures and overall survival (OS) and disease free survival (DFS) 2) analysis of the success rate of establishment of colon organoids derived from patient material in a standardized clinical setting 3) We will further explore new intervention approaches that are effectively targeting the distinct subtypes, which will be carried forward into a spectrum of in vitro and in vivo models in order to develop these therapies for future use 4) In addition we will try to define the role of distinct mutations and the regulation of EMT mesenchymal features in colon cancer and to identify key players in this process in order to identify resistance mechanisms that play a role in this subgroup of cancers.	—

Measure

Time frame

Secondary research questions include 1) association between non-responsiveness of the primary cultures and overall survival (OS) and disease free survival (DFS) 2) analysis of the success rate of establishment of colon organoids derived from patient material in a standardized clinical setting 3) We will further explore new intervention approaches that are effectively targeting the distinct subtypes, which will be carried forward into a spectrum of in vitro and in vivo models in order to develop these therapies for future use 4) In addition we will try to define the role of distinct mutations and the regulation of EMT mesenchymal features in colon cancer and to identify key players in this process in order to identify resistance mechanisms that play a role in this subgroup of cancers.

—

Countries

Netherlands

Outcome results