The effect of dietary salt intake on proximal tubular endocytic function

The effect of dietary salt intake on proximal tubular endocytic function - SALT

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON45413

Enrollment

Registered

2017-05-09

Start date

2017-05-21

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

proteinuria urinary protein loss

Interventions

All participants will be sequentially placed on a low salt and a high salt diet.

kidney

proteinuria

sodium

tubule

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - Age 18-30 years - Male sex

Exclusion criteria

Exclusion criteria: - Use of any medication - Smoking - History of hypertension, cardiovascular / metabolic / renal / urogenital / hepatic disease, substance abuse - eGFR 20 mg/10 mmol creatinine in spot urine - Hypertension at screening visit (>140/90 mmHg by office blood pressure measurement) - Urinary tract infection at screening visit - Participation in evening or night shift work during the study period and the week before enrolment - BMI > 27 kg/m2 - Inability to adhere to the study protocol (due to language or cognitive disability)

Design outcomes

Primary

Measure	Time frame
Proximal tubular endocytic function.	—

Secondary

Measure	Time frame
Blood pressure, RAS components, kidney function, serum and urine electrolytes, body fluid composition	—

Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)