Empirical hemodynamic models of micro- and macro-vessels in the brain: an fMRI and RespirActTM approach

Empirical hemodynamic models of micro- and macro-vessels in the brain: an fMRI and RespirActTM approach - Hemodynamic models

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON45408

Enrollment

Registered

2017-04-19

Start date

2018-03-07

Completion date

Unknown

Last updated

2026-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Een specifieke aandoening maakt geen onderdeel uit van dit onderzoek (gezonde vrijwilligers). Na (healthy volunteers)

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Informed consent; - 18 years or older.

Exclusion criteria

Exclusion criteria: Part I (fMRI with RespirAct): - Standard contra-indications for 3T or 7T MRI scanning; - Unwilling or unable to co-operate with breathing manoeuvres; - Respiratory or cardiac limitations to breathing at 20 L/min; - Medical contra-indications to limited hypercapnia or hypocapnia (known increased intracerebral pressure, metabolic acidosis or alkalosis); - Known vascular brain disease.;Part II (fMRI without RespirAct): - Standard contra-indications for 3T or 7T MRI scanning.

Design outcomes

Primary

Measure	Time frame
Establishment and modelling (quantification) of hemodynamic changes for different vessel groups in the human brain in response to external stimulation.	—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results