PARDS
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: Informed consent Age younger than 12 years Need for mechanical ventilation with tidal volume 5 - 8 mL/kg ideal bodyweight and a mimum PEEP level of 5 cmH2O Early moderate - to - severe paediatric acute respiratory distress syndrome originating from any cause: • Acute onset of disease, and • Oxygenation index > 12, and • One or more (bilateral) infiltrates on chest radiograph, and • No evidence of left ventricular failure or fluid overload, and • Within the first 48 hours of diagnosis of PARDS Indication for continuous infusion of NMBAs at discretion of the attending physician
Exclusion criteria
Exclusion criteria: No informed consent Continuous administration of neuromuscular blockade prior at the time of meeting the criteria for PARDS Chronic respiratory failure on home ventilation Intracranial hypertension Bone marrow transplantation Immunocompromised patients (congenital or acquired) Pre-existing pulmonary hypertension Congenital heart disease with left - to - right shunting Cyanotic congenital heart disease Withdrawal of life - sustaining treatment Prematurity (gestational age less than 44 weeks when assessed for eligibility) History of congenital neuromuscular disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Transpulmonary pressure | — |
Secondary
| Measure | Time frame |
|---|---|
| Haemodynamic profile, respiratory system mechanics, metrics for oxygenation, ventilation and deadspace, and diaphragmatic activity and occurrence of pendelluft | — |
Countries
Netherlands
Outcome results
None listed