Guiding personalized treatments for Parkinsons tremor with individual neuroimaging an exploratory study

Guiding personalized treatments for Parkinson*s tremor with individual neuroimaging * an exploratory study - Tremor fingerprints in Parkinson's disease

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON45367

Enrollment

Registered

2017-05-03

Start date

2018-01-25

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease tremor

Interventions

Parkinson

tDCS

tremor

The intervention involves TACS, which is a non-invasive, non-painful way of stimulating underlying cortical brain tissue through electrodes applied to the scalp. When applied rhythmically at the fre

fMRI

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - Idiopathic Parkinson*s disease according to UK brain bank criteria. - Presence of a clear resting tremor of at least one arm (UPDRS tremor-score > 2).

Exclusion criteria

Exclusion criteria: - neuropsychiatric co-morbidity - contraindications for MRI scanning (e.g. pacemaker, implanted metal parts, deep brain stimulation, claustrophobia) - Severe head tremor or dyskinesias. - Cognitive impairment (MMSE

Design outcomes

Primary

Measure	Time frame
(1) Within-subjects reproducibility of tremor-related activity and connectivity (tremor fingerprint; quantified using concurrent EMG-fMRI across two different days); (2) Modulation of tremor-related activity and connectivity by TACS (comparison of the three TACS conditions); (3) Modulation of tremor by TACS (quantified using accelerometry), and its correlation with network parameters derived from the tremor circuit (i.e. thalamo-cortical connectivity).	—

Measure

Time frame

(1) Within-subjects reproducibility of tremor-related activity and connectivity (*tremor fingerprint*; quantified using concurrent EMG-fMRI across two different days); (2) Modulation of tremor-related activity and connectivity by TACS (comparison of the three TACS conditions); (3) Modulation of tremor by TACS (quantified using accelerometry), and its correlation with network parameters derived from the tremor circuit (i.e. thalamo-cortical connectivity).

—

Secondary

Measure	Time frame
Not applicable. See Primary outcome measure.	—

Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)

Guiding personalized treatments for Parkinson*s tremor with individual neuroimaging * an exploratory study