visual snow
Conditions
Interventions
clinical description
cortical hyperexcitability
migraine
visual snow
Sponsors
Neurologie
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: General * Age *18 years (and
Exclusion criteria
Exclusion criteria: General exclusion criteria for those willing to participate in case-control measurements * Subjects who do not want to be informed about unexpected findings that are considered serious and have prognostic or therapeutic consequences * Schizophrenia, bipolar disorder, other psychotic disorders in medical history or current clinical suspicion of psychosis (delusions) * Malignancy in medical history * Central nervous system disease in medical history (other than migraine) * For those participating in MRS: Pacemaker or ICD, Metal implants which cannot be removed, Pregnancy, Claustrophobia;Visual snow * Underlying neurological disorder or ophthalmological disorder explaining symptoms (for case-control measurements only (3.2), not an exclusion criterion for clinical description (3.1)) ;HPPD * Underlying neurological disorder or ophthalmological disorder explaining symptoms (for case-control measurements only (3.2), not an exclusion criterion for clinical description (3.1)) * Clinical suspicion that visual symptoms are part of psychosis, delirium, neurodegenerative disease or hypnopompic hallucinations ;Migraine patients with frequent auras * Meeting criteria for any other (comorbid) headache disorder except for tension type headache * Clinical suspicion that patient has Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL; often presents with frequent auras) or any other hereditary cerebral amyloid angiopathy * (History of) ophthalmological disease other than refraction error * (History of) chronic tinnitus;Tinnitus patients * Any symptoms of migraine, cluster headache, chronic tension type headache or medication overuse headache * (History of) ophthalmological disease other than refraction error;Healthy controls * Any symptoms of migraine, cluster headache, chronic tension type headache or medication overuse headache * (History of) ophthalmological disease other than refraction error * (History of) chronic tinnitus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Detailed clinical information on different visual symptoms, non-visual symptoms, triggers, (psychiatric and neurological) comorbidities and psychological well-being; including data from prospective follow-up. 2. Quantitative data on visual sensitivity and EEG and VEP profiles with specific parameters (amplitude of the posterior dominant rhythm, photic drive response); including diagnostic test characteristics. 3. Concentrations of multiple metabolites both in vivo (MRS) and ex vivo (blood, urine). | — |
Countries
The Netherlands
Outcome results
None listed