Acute and delayed effects of THC intoxication on false memories in a legal context

Acute and delayed effects of THC intoxication on false memories in a legal context - Effects of THC intoxication on false memories in a legal context

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON45359

Enrollment

Registered

2017-01-23

Start date

2017-05-10

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

no health condition is addressed in the research, and healthy volunteers who are occasional cannabis users will be recruited n.a.

Interventions

Placebo (Knaster Hemp) and bedrobinol (300 µg THC/kg bodyweight)

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Occasional cannabis users (used between 1 times a month and 1 times a week during the previous year) Aged between 18 and 40 years Free from psychotropic medication Good physical health as determined by medical examination and laboratory analysis Absence of any major medical, endocrine and neurological condition Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2 Written Informed Consent Good knowledge and understanding of the English language (at least 5 years of English language education; assessed in the pre-screening)

Exclusion criteria

Exclusion criteria: History of drug abuse (other than the use of cannabis) or addiction (determined by the medical questionnaire, drug questionnaire and medical examination) Pregnancy or lactation (pregnancy test, if needed) Hypertension (diastolic> 90; systolic> 140) Current or history of psychiatric disorder (determined by the medical questionnaire and medical examination) Liver dysfunction (Serious) side effects due to previous cannabis consumption History of cardiac dysfunctions (arrhythmia, ischemic heart disease,*)

Design outcomes

Primary

Measure	Time frame
Primary: Spontaneous false memories will be measured using the Deese/Roediger-McDermott (DRM) paradigm. Suggestion-based false memories will be assessed via exposing subjects to a virtual reality mock crime and adding suggestive misinformation in subsequent interrogations.	—

Secondary

Measure	Time frame
Secondary: Dissociative psychopathology (i.e., dissociative traits) will be measured using the Dissociative Experiences Scale (DES). Reality monitoring/dissociative symptoms (i.e., dissociative states) will be assessed using the Clinician Administered Dissociative States Scale (CADSS). Other parameters include constructs related to (false) memory, such as attention, information processing, compliance, arousal, and convergent and divergent thinking.	—

Measure

Time frame

Secondary: Dissociative psychopathology (i.e., dissociative traits) will be measured using the Dissociative Experiences Scale (DES). Reality monitoring/dissociative symptoms (i.e., dissociative states) will be assessed using the Clinician Administered Dissociative States Scale (CADSS). Other parameters include constructs related to (false) memory, such as attention, information processing, compliance, arousal, and convergent and divergent thinking.

—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)