inspanningscapaciteit muscle function oxidative capacity
Conditions
Interventions
Exercise training: During the 12-week exercise training program participants
will complete three exercise sessions weekly. In the training programs
continuous endurance exercise sessions will be alt
Sponsors
Hogeschool van Arnhem en Nijmegen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Male Age between 18 and 40 years of age BMI between 18 * 30 kg/m2 Untrained or recreationally active (i.e. performing sports on a non-competitive basis for a maximal duration of 6 hours per week). VO2max *50 ml/kg/min Willing to give blood samples Able to be present at required test days Able to perform three exercise sessions weekly for 12 weeks
Exclusion criteria
Exclusion criteria: Blood donation during the study period Lactose intolerance and/or dairy protein allergy Consumption of >21 alcoholic beverages per week Use of illicit drugs Use of antibiotics in the past month Medical condition that can interfere with the study outcome (i.e. cardiovascular disease, pulmonary disease, rheumatoid arthritis, orthopedic disorders, renal disease, liver disease, diabetes mellitus, inflammatory disease, cognitive impairment) Use of medications known to interfere with selected outcome measures (i.e. statins, fenofibrate, beta-blocker, corticosteroids) (Chronic) injuries of the locomotor system that can interfere with the intervention Current participation in other biomedical research study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maximal oxygen uptake (VO2max): VO2max will be assessed by indirect calorimetry during an incremental exercise prototocol on a cycling ergometer (indirect calorimetry). | — |
Secondary
| Measure | Time frame |
|---|---|
| Exercise performance: Exercise performance will be assessed by a 10 km time trial. Muscle function: Maximal strength and muscular endurance will be assessed by isokinetic dynamometry. Body composition: Whole body and regional body composition will be assessed by a DXA scan and by skinfold measurements according to ISAK standards (International Society for the Advancement of Kinanthropometry). Hematological and biochemical variables (blood): complete blood count, ferritin, CRP, and markers of bone and joint health. Mitochondrial function: Mitochondrial function will be assessed in peripheral blood mononuclear cells (PBMCs) | — |
Countries
Netherlands
Outcome results
None listed