Study in HIV negative controls using BOLD functional MRI

Study in HIV negative controls using BOLD functional MRI - SHERLOC

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON45334

Enrollment

Registered

2017-03-14

Start date

2017-08-20

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cognitieve aandoeningen cognitieve achteruitgang verstandelijke achteruitgang

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Male, between 25 and 50 years - HIV-negative at screening visit - Negative TPHA or VDRL

Exclusion criteria

Exclusion criteria: - Proven major depression through psychiatric consultation within the past year or on anti-depressant drugs - History of proven neurologic disease (e.g. multiple scleroses, brain tumour, cerebrovascular event, etc.) - Active psychiatric disorders classified according to the DSM V criteria - History or evidence of alcohol or drug abuse according to the DSM V criteria - TSH not within normal reference values - Contraindications for undergoing an MRI according to standard UMCU MRI protocol; a pacemaker or metallic device in situ, proven claustrophobia.

Design outcomes

Primary

Measure	Time frame
Brain activation measured with BOLD fMRI when performing specified tasks	—

Secondary

Measure	Time frame
Brain activation measured with BOLD fMRI when performing an inhibition task Brain activation measured with BOLD fMRI when performing a reward task Brain connectivity measured with BOLD fMRI during resting state	—

Countries

Netherlands

Outcome results