born without the sense of smell congenital anosmia
Conditions
Interventions
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: For patients, in order to be eligible to participate in this study, a subject must meet all of the following criteria: - Have congenital anosmia - Labelled as anosmic according to our standardized clinical olfactory test - Age between 18-65 years - Have a normal eyesight or an eye deviation that can be corrected with glasses or contact lenses. - Willing to comply with the study procedures - Willing to be informed about incidental findings of pathology - Having given written informed consent;For age- and sex- matched healthy controls, in order to be eligible to participate in this study, a subject must meet all of the following criteria: - Self-reported healthy - No know smell disorder - Labelled as having a normal sense of smell according to our standardized clinical test - Age between 18-65 years - Have a normal eyesight or an eye deviation that can be corrected with glasses or contact lenses. - Willing to comply with the study procedures - Willing to be informed about incidental findings of pathology - Having given written informed consent - Matched on sex to patient - Matched on age (within 3 years) to patient
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - Being deaf (or having any other hearing problems) or blind - Being an employee of the division of Human Nutrition, Wageningen University - Performing an internship or thesis at the chair group Sensory Science and Eating Behaviour of the division of Human Nutrition, Wageningen University - Having a contra-indication to MRI scanning (including, but not limited to): * Pacemakers and defibrillators * Intraorbital or intraocular metallic fragments * Ferromagnetic implants * Presence of non-removable piercings
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main parameters within this study are: - Morphological (anatomical) differences in brain areas between healthy and anosmic individuals. - Differences in functional connectivity during resting-state between healthy and anosmic individuals. - Differences in functional connectivity during uni- versus multi-sensory stimulation within healthy and anosmic individuals. - Differences in functional connectivity during uni- and multi-sensory stimulation between healthy and anosmic individuals. | — |
Secondary
| Measure | Time frame |
|---|---|
| A secondary study parameter are differences between groups in behavioral outcomes of the multisensory integration task. This will be calculated by means of Hierarchical Drift Diffusion Model (HDDM), to combine speed versus accuracy in responses. | — |
Countries
Netherlands, Sweden, Switzerland, Taiwan (Province of China)
Outcome results
None listed