coagulation hemostasis reducing bleeding mechanism
Conditions
Interventions
- Coagulation
- Hemostasis
- Liver transplantation
- Pediatric
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: Study group - Patients that undergo orthotopic liver transplantation for any reason at the UMCG, except patients with acute liver failure - Livers from all sort of donors will be included, including living donor livers - In the period from june 2017 to june 2018 - Signed informed consent (patients and/or parents/guardian);Control group - Healthy patients that undergo minor surgery at the UMCG Minor surgery includes inguinal operations and excision of soft tissue tumours other than malignancy, like a cyst, hemangioma or lipoma. - In the period from june 2017 to june 2018 - Matched 2:1 with the study group population for age - Signed informed consent (patients and/or parents/guardian)
Exclusion criteria
Exclusion criteria: Study group - Age > 16 years - No informed consent obtained - Diagnose of acute liver failure;Control group - Age > 16 years - No informed consent obtained - Any comorbidities or pre-term birth - Use of medication that influences liver function or hemostasis - History of thrombotic events or bleeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Routine diagnostic tests of hemostasis (platelet count, prothrombin time), thrombin generation tests, and thromboelastography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not applicable. | — |
Countries
The Netherlands
Outcome results
None listed