Von Willebrand Factor to Identify high-risk patients with aortic Stenosis during Exercise - WISE study

Von Willebrand Factor to Identify high-risk patients with aortic Stenosis during Exercise - WISE study - WISE

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON45303

Enrollment

Registered

2017-02-27

Start date

2017-01-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic valve narrowing Aortic valve stenosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age * 18 years - Moderate aortic stenosis or asymptomatic severe aortic stenosis, confirmed in the past 3 months by echocardiographic evaluation - Ability to undergo exercise stress testing - Ability to understand and the willingness to sign a written informed consent.

Exclusion criteria

Exclusion criteria: - Unrevascularized and severe coronary artery disease (for example a 90% diameter stenosis or FFR

Design outcomes

Primary

Measure	Time frame
To evaluate whether vWF (von Willebrand multimer ratio and CT-ADP) changes over time as a result of exercise in patients with moderate aortic stenosis and asymptomatic severe aortic stenosis and to determine the mean time from the start of exercise to the peak of vWF change. This pilot study will be the first study to address this question.	—

Secondary

Measure	Time frame
To assess the relationship between changes in vWF during exercise and adverse events (death, AVR/TAVI, heart failure, syncope, angina, bleeding). We will follow up the patients untill 1 year after the exercise test and ask them the appearence of the adverse events.	—

Countries

Netherlands

Outcome results