Pijngeneeskunde postoperative pain after inguinal hernia repair
Conditions
Interventions
The following NAC infusion regimen will be conducted. One hour prior to
surgery, the patients will receive 150 mg/kg in 200 ml intravenous bolus over
15 minutes. During NAC infusion, patients vital
inguinal hernia
N-Acetylcysteïne
pain
postoperative
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: subjects ASA 1-2 sceduled for laparoscopic inguinal hernia repair
Exclusion criteria
Exclusion criteria: - Pregnancy or lactating - Allergy to NAC - History of chronic pain - Use of opioids or neuropathic analgesics - Use of NAC prior to trial (1.5x upper limit of normal) - No written IC by patient
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary objective is to evaluate the efficacy of intravenous NAC in comparison with placebo in terms of pain relief after unilateral inguinal hernia repair measured by a visual analogue scale (VAS 0-100) at day 1 after surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| * Pain scores (VAS 1-100) direct postoperatively , before discharge and in following 3 days postoperative. * Time to first necessity of pain medication after surgery (in minutes). * Total consumption of in hospital opiates (in mg). * Time to discharge (in minutes). * Analgesic medication taken at home by patient (registered by patients in diary) (in mg). * Adverse effect of analgesic medication (nausea, obstipation, sedation) (in numbers). | — |
Countries
The Netherlands
Outcome results
None listed