The cerebral mechanisms underlying dystonic and essential tremor: a multimodal network approach

The cerebral mechanisms underlying dystonic and essential tremor: a multimodal network approach - Cerebral mechanisms in dystonic and essential tremor

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON45276

Enrollment

Registered

2017-04-06

Start date

2017-10-20

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dystonia

Interventions

The intervention involves transcranial alternating current stimulation (TACS), which is a non-invasive, non-painful way of stimulating underlying cortical brain tissue through electrodes applied to

Dystonia

Essential tremor

Neuroscience

Tremor

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: For essential tremor patients: -Clinical diagnosis of essential tremor -Postural tremor of both hands -Onset of tremor before the age of 65 (to exclude pathophysiological heterogeneity caused by age-related tremor [15]);For dystonic tremor patients: -Clinical diagnosis of dystonic tremor -Primary focal / segmental dystonia -Presence of postural tremor of at least one arm (which may or may not be the dystonic limb)

Exclusion criteria

Exclusion criteria: -Neurological co-morbidity -Moderate to severe head tremor (to avoid artifacts caused by extensive head motion during scanning) -Cognitive dysfunction (clinical diagnosis of mild cognitive impairment or dementia) -MRI or TACS contraindications

Design outcomes

Primary

Measure	Time frame
We will use concurrent EMG-fMRI to localize and compare tremor-related activity between both groups (outcome #1) - an approach we have previously validated in Parkinson*s tremor.	—

Secondary

Measure	Time frame
Given the hypothesized role of inhibitory GABA-ergic circuits in both tremor types, we will use 3T magnetic resonance spectroscopy to compare GABA concentrations in the internal globus pallidus, cerebellum, and motor cortex between both groups (outcome #2). Also, we use a non-invasive, adaptive and controlled brain stimulation approach (transcranial alternating current stimulation; TACS) to test for the effect of inhibiting the motor cortex and cerebellum on tremor intensity (accelerometry) and, for the cerebellum, on tremor-related activity (EMG-fMRI) and (outcome #3). Previous research has shown powerful modulatory influences of TACS on both Parkinson*s tremor and ET.	—

Measure

Time frame

Given the hypothesized role of inhibitory GABA-ergic circuits in both tremor types, we will use 3T magnetic resonance spectroscopy to compare GABA concentrations in the internal globus pallidus, cerebellum, and motor cortex between both groups (outcome #2). Also, we use a non-invasive, adaptive and controlled brain stimulation approach (transcranial alternating current stimulation; TACS) to test for the effect of inhibiting the motor cortex and cerebellum on tremor intensity (accelerometry) and, for the cerebellum, on tremor-related activity (EMG-fMRI) and (outcome #3). Previous research has shown powerful modulatory influences of TACS on both Parkinson*s tremor and ET.

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Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)