hypertensie chronic kidney disease loss of kidney function
Conditions
Interventions
Functional MRI
Inulin clearance
Kidneys
Renal function
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Subject is >= 18 years of age - Subject agrees to have all study procedures performed, and is competent and willing to provide written, informed consent to participate in this clinical study;Exclusively for subjects in the CKD group: - Subject has a GFR of 30-60 ml/min/1.73 m2 ;Exclusively for subjects in the hypertension group: - Subject has a systolic blood pressure of >=140 mmHg and/or a diastolic blood pressure of >=90 mmHg based on average of 3 office blood pressure readings, or a 24-h ambulatory blood pressure of >=140 mmHg systolic and/or >=90 mmHg diastolic; or is on antihypertensive medication - Subject has no treatable secondary cause of hypertension - Subject has no medical record of impaired kidney function (as defined by a GFR =140 mmHg and/or a diastolic blood pressure of >=90; or the use of antihypertensive medication) - Subject can be age matched within a range of ±5 years to one or more subjects in the CKD and hypertension groups
Exclusion criteria
Exclusion criteria: - Subject has an allergy or intolerance to any of the agents used in the study - Subject has any contraindications for MRI according to screening protocol radiology department UMCU - Subject is pregnant, nursing or planning to be pregnant - Subject has a known, unresolved history of drug use or alcohol dependency, lacks the ability to comprehend or follow instructions, or would be unlikely or unable to comply with study follow-up requirements - Subject refuses to be informed of chance findings possibly relevant to their health - Subject is currently being treated with drugs that cause salt retention (e.g., systemic corticosteroids and fludrocortisone);Exclusively for healthy volunteers and hypertensive subjects: - Subject has no known renal disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Agreement between GFR as measured with MRI and GFR as measured with inulin clearance. | — |
Countries
The Netherlands
Outcome results
None listed