does not apply
Conditions
Interventions
None listed
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Healthy subject 2. Caucasian male: 18-45 years old 3. Well trained recreational cyclists 4. Written informed consent obtained.
Exclusion criteria
Exclusion criteria: 1. Body mass index (BMI) 25 kgm2 2. Known cardiopulmonary disease, or ECG or spirometrie suggestive of cardiopulmonary disease 3. Active smoking, smoking history; >5 packyears 4. Hypertension; defined as blood pressure > 140/90 mmHg (millimeters of mercury). 5. Renal failure; defines as Estimated Glomerular filtration rate (eGFR) using Modification of Diet in Renal Disease (MDRD) formula;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective of this study is to determine whether the analysis of breath-to-breath respiratory variability provide more information on the mechanism that is responsible for the RCP. The main study parameters are the breath-to-breath variability of VT, TI and TE. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objectives of this study are to assess the RCP acting as phenomenon, and the timing of the anaerobic threshold (AT) and lactic acidosis in relationship to the RCP | — |
Countries
Netherlands