alzheimer's disease dementia
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients: 1) A diagnosis of subjective cognitive decline, mild cognitive impairment (MCI) or dementia due to Alzheimer's Disease (AD) OR MCI or mild dementia due to Dementia with Lewy bodies (DLB); 2) MMSE >= 18; 3) Age >= 50; 4) Written informed consent; 5) Availability of a primary caregiver;Control group: age >= 50, cognitively normal
Exclusion criteria
Exclusion criteria: Presence of a neurological disease other than AD or DLB; Presence of another major psychiatric disorder (according to Diagnostic and Statistical Manual of Mental Disorders, 4th version); Current abuse of alcohol or drugs; Currently participating in a clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is clinical progression in cognition and everyday functioning, as measured with the CFC. Reference measures for this progression consist of cognitive screening tests, caregiver-based anchor measurements of change and Magnetic Resonance Imaging (MRI). Progression of disease burden will be assessed using caregiver burden, quality of life and level of apathy measures and social functioning. For the validation of the CFC, we will relate changes on the CFC to these other measures of disease progression. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters are age, gender, education, culture and disease severity at baseline. We will investigate their possible influence on the CFC. | — |
Countries
Netherlands
Outcome results
None listed