hersenen, focale epilepsie refractory focal epilepsy
Conditions
Interventions
Eligible patients will be randomised, after informed consent is signed, into
group 1 (HFOs) in whom a resection of epileptogenic tissue is guided by HFOs in
the aECoG (new), or into group 2 (spikes)
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients of all ages with: - Focal epilepsy that are planned for neurosurgery with aECoG, with the goal of tailoring the resection. -Command of Dutch language of the patient/parents/legal representatives and capability of completing the questionnaires (by email or phone).
Exclusion criteria
Exclusion criteria: - Patients who underwent chronic ECoG monitoring preceding epilepsy surgery. - Patients with an occipital focus undergoing aECoG. - Patients with tailored tumor surgery with expected progressive course of disease (e.g. expected tumor growth, planned radiotherapy after surgery).*
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcome after epilepsy surgery after 1 year of follow-up dichotomized in total seizure freedom (Engel classification Ia&b) vs. seizure recurrence (Engel classification Ic-IV). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secundary study parameters are pre- vs post opertive differences in volume of brain tissue removed, neurological deficits, cognitive functioning, duration of surgery and aECoG recording and health related quality of life (QoL). | — |
Countries
Netherlands
Outcome results
None listed