non-affective psychotic disorder psychosis
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: For patients: 1) meeting DSM-IV criteria for schizophrenia, schizophreniform disorder, schizoaffective disorder or psychotic disorder NOS; 2) in case of psychiatric comorbidity, the schizophrenia spectrum disorder is predominating; 3) age between 18-55; 4) speaking Dutch fluently; 5) being able to give informed consent.;Healthy controls must fulfill the following criteria: 1) age between 18-55; 2) speaking Dutch fluently; 3) being able to give informed consent.
Exclusion criteria
Exclusion criteria: 1) other psychiatric disorders than above mentioned schizophrenia spectrum disorders; that presumably affect our data; 2) the presence of accompanying neurological disorders that supposedly influence our data; 3) visually acuity less than 50 percent (Snellen chart); 4) visually field defects (Donders technique); 5) cognitive impairment, which is assessed by Mini-Mental State Examination. The cut-off point is
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary parameter of the first party of the study is object and space perception, assessed by the Visual Object and Space Perception (VOSP) battery. Object perception is also assessed by Image Recognition Movies (IRM). The VOSP consists of four tests assessing object perception and four tests assessing space perception. It minimizes the involvement of other cognitive systems. They have to do the test in writing. The IRM compromises 4 movies in which objects dynamically appear out of random noise, mimicking suboptimal visual situations. Subjects have to verbally name the image when recognized. The speed and content of conscious perception will be assessed. The primary parameter of the second part of the study is the fMRI-scan-output while the IRM test is performed. The primary endpoint of the retinotopic mapping fMRI-scans is cortical activation, reflected by the Blood-Oxygen-Level-Dependent (BOLD)-level. During this retinotopic mapping, participants are presented with a bar and wedges with a checkerboard pattern which moves across the screen, The primary endpoint of the resting-state fMRI-scans with pushing buttons for VH is also cortical activation, reflected by the Blood-Oxygen-Level-Dependent (BOLD)-level. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objective is attention. The Test Battery of Attentional Performance (TAP) was applied for this objective. Participants have to focus their visual attention for 10 minutes on a computer screen for this test and have to push a button if they recognize irregularities in movement patterns. It measures the number of omitted irregularities for sustained visual attention. An other type of attention, working memory, is assessed by the Wechsler Adult Intelligence Scale II Word Learning and Recalling Task. Participants are presented with 15 words on a computer screen, then they have to try recall those 15 words. This is repeated twice. The total correct remembered words are measured, as are the number of wrong answers and number of words named twice (or more times). After 20 minutes, they are asked to recall the 15 words (delayed recall). Also, they are presented with 30 words, which include the 15 presented words as well as 15 words which were not presented. They are asked whether they have been presented with the particular words. The number of correct hits and correct rejections are measured. An other secondary objective is auditory perception. .A speech discrimination test has been applied for this objective (22).Subjects are seated in front of a computer screen, wearing a headphone. On each trial a target word is presented at 60-65 dB, superimposed on white background noise at 72 dB. The target words are audible but hardly discernable. Stimuli consists of verbs and nouns. After a 2-seconds* delay a probe stimulus, consisting of a spoken word, is presented, free of noise, and thus clearly audible. During this phase the screen showed only a fixation cross. The question *have you heard the word *X* in the noise?*is then presented on the screen, with *X* referring to the probe stimulus. Subjects indicate their answer on a five-point scale, ranging from *certainly not* to *certainly*. The experiment consists of 50 trials. On half of the | — |
Countries
Netherlands
Outcome results
None listed