deafness hearing loss
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - Aged 18 or older - Normal function of middle ear, i.e., no acute middle ear infections, no tympanic membrane perforations and an air bone gap (which reflects middle-ear function) = 70 dB HL. - *Deaf* ear has been deaf for no longer than 10 years - Hearing in *normal* ear: hearing threshold for individual frequencies (0.5, 1, 2, 4 kHz)
Exclusion criteria
Exclusion criteria: A subject who meets any of the following criteria will be excluded from participation in this study: - Abnormal cochlear anatomy in one or both ears (i.e. malformation or ossification). - Disability which could interfere with the completion of the tests (i.e. psychiatric problems). - Patients with contraindications for Magnetic Resonance Imaging (MRI) - not fulfilling the criteria of the MRI inclusion list, including the presence of a pacemaker and pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of fractional anisotropy (FA) and mean diffusivity (MD) of the auditory nerve between normal and deaf sides Furthermore, FA and MD will be correlated with duration of deafness. Other DTI metrics may be considered as well. | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between the DTI parameters and eCAP parameters of patients who receive a CI. Correlation of DTI and eCAP parameters with duration of deafness. Reproducibility of DTI measures. | — |
Countries
Netherlands
Outcome results
None listed