cognitieve functies memory function small cell lung cancer
Conditions
Interventions
Patient will receive prophylactic brain irradiation in 10 fractions
Sponsors
Nederlands Kanker Instituut
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * SCLC patients (stage I-III or stage IV without clinical or radiological evidence of brain metastases) candidate for PCI, i.e. without progressive disease after chemo-radiotherapy in stage I-III or after a remission after chemotherapy in stage IV * WHO-performance status * 2(see Appendix IV). * Sufficient proficiency in Dutch language * Written informed consent must be given according to ICH/GCP, national and local regulations
Exclusion criteria
Exclusion criteria: * Prior radiotherapy to the brain * clinical evidenceof brain metastases or primary brain tumors * Evidence of progressive extracranial metastatic disease * Previous malignancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess memory function at 4 months after PCI versus HA-PCI. A decline of 5 points in the total recall score will be considered as a failure. | — |
Secondary
| Measure | Time frame |
|---|---|
| * To assess early and late neurotoxicity and quality of life following PCI with or without hippocampal sparing. * To assess structural brain damage from PCI on MRI with and without sparing of the hippocampus. * To assess the incidence and location of brain metastases after PCI with or without hippocampal sparing. * Overall survival. | — |
Countries
Netherlands
Outcome results
None listed