Breast cancer mammacarcinoom
Conditions
Interventions
None listed
Sponsors
Haaglanden Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Histological confirmed breast cancer (DCIS and invasive) ductal subtypes T1-2 smaller than 30mm as determined by ultrasound N0 on palpation and ultrasound examination Unicentric, Unifocal disease (radiological), multifocal when limited within 2 cm of the index lesion) Age * 60 Any hormonal receptor status, hormonal therapy allowed following Dutch treatment guidelines Technically eligible for lumpectomy or radiotherapy No contra indications for lumpectomy and sentinal node procedure Written informed consent Willing to fill out the QOL, geriatric- and co morbidity questionaires - if applicable
Exclusion criteria
Exclusion criteria: Patients not eligible / fit for lumpectomy and sentinal node procedure pT2 (>30mm), pT3 and pT4 Positive surgical margins Multi centricity; multifocal (> 2cm from the index lesion) Extensive intraductal carcinoma; lympho-vascular invasion Previous treatment of ipsilateral breast tumor (DCIS or invasive) Paget disease of the nipple Cutaneous involvement Distant metastases; > pN1a Previous radiotherapy on the ipsilateral breast neo adjuvant chemotherapy for current malignancy Collagen diseases (systematic erythematosus lupus, scleroderma, dermatomyositis) Psychiatric diseases or other that prevents signing of informed consent Other neoplasm's in the last 5 year with exception of skin tumors (excl melanoma) and intraepthelial lesions of the cervix uteri
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Confirm favorable tumor control and cosmetic outcome (2 toxicity, 90% good/excellent cosmetic result). | — |
Secondary
| Measure | Time frame |
|---|---|
| Gathering QOL, geriatric and other information for modeling patient outcome. EORTC QOL C30/ breast module, ACE 27, registration multi-pharmacy, geriatric screening questionnaire (incl. GFI ,G8 and VES 13). Also digital pictures will be made after 3 and 5 years for objective cosmetic results. | — |
Countries
Netherlands
Outcome results
None listed