Effects of hyperbaric oxygen therapy on resuscitating mucosal microcirculation and tissue repair in patients who received radiotherapy for malignant disease in the head and neck region

Effects of hyperbaric oxygen therapy on resuscitating mucosal microcirculation and tissue repair in patients who received radiotherapy for malignant disease in the head and neck region - Response of microcirculation to hyperbaric oxygen therapy.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON45130

Enrollment

Registered

2014-07-01

Start date

2014-11-28

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bloedoorstroming in de microvaten atrophy of the epithelium decreased vascularity obliterative endarteritis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Patients referred to the Department of Hyperbaric Medicine in the AMC for treating osteoradionecrose and nonhealing ulcerations associated with a previous history of RT in the head and neck region. • Patients referred to the Department of Hyperbaric Medicine in the AMC for HBOT prior to and after surgical intervention in the irradiated oral tissue. • Patients >=18 years. • Informed consent.

Exclusion criteria

Exclusion criteria: • Patients with oral surgery within the last month prior to the start of the investigation. • Trismus that complicates sufficient mouth opening for measurements. • Mucosa that is to painful for measurements. • Patients

Design outcomes

Primary

Measure	Time frame
- Capillary enumeration (i.e. counting of the capillary loops present in each visual field). The average from 5 captured video frames will be computed and recorded to represent the capillary density at each time point in all patients. - We will make a close observation of the morphology. Given that we do not know what to expect, this will not be quantified other than noted descriptively afterwards.	—

Measure

Time frame

- Capillary enumeration (i.e. counting of the capillary loops present in each visual field). The average from 5 captured video frames will be computed and recorded to represent the capillary density at each time point in all patients. - We will make a close observation of the morphology. Given that we do not know what to expect, this will not be quantified other than noted descriptively afterwards.

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Secondary

Measure	Time frame
-	—

Countries

Netherlands

Outcome results