Early detection of cardiovascular risk factors after pregnancy complicated by hypertensive disorders or spontaneous preterm birth

Early detection of cardiovascular risk factors after pregnancy complicated by hypertensive disorders or spontaneous preterm birth - HyPreCare

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON45089

Enrollment

687

Registered

2013-04-24

Start date

2014-09-07

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiovascular disease after hypertensive disorders in pregnancy or after spontaneous preterm birth

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Women with a history of early preeclampsia (

Exclusion criteria

Exclusion criteria: Multiple pregnancy, chronic hypertension, diabetes mellitus before pregnancy or gestational diabetes during the index pregnancy, cardiovascular disease before pregnancy, renal disease, coagulation disorders, history of pregnancy complicated by fetal anomalies. For SPTB cases also: iatrogenic preterm birth, uterine anomaly, history of conisation of the cervix For controls exclusion: no pregnancies complicated by vascular complications.

Design outcomes

Primary

Measure	Time frame
Specific targets to identify women suitable for secondary prevention of cardiovascular disease at a relatively young age. Preeclampsia study part: -Vascular dysfunction primary outcome: difference in prevalence of the metabolic syndrome and/or circulating microparticles between cases and controls -Diastolic dysfunction primary outcome: difference in diastolic heart function or heart failure between cases and controls. Spontaneous preterm birth study part: -Vascular dysfunction primary outcome: difference in prevalence of hypertension and/or circulating microparticles between cases and controls -Diastolic dysfunction primary outcome: difference in the E*mean, one of the cardiac ultrasound parameters of diastolic heart function, between cases and controls.	—

Measure

Time frame

Specific targets to identify women suitable for secondary prevention of cardiovascular disease at a relatively young age. Preeclampsia study part: -Vascular dysfunction primary outcome: difference in prevalence of the metabolic syndrome and/or circulating microparticles between cases and controls -Diastolic dysfunction primary outcome: difference in diastolic heart function or heart failure between cases and controls. Spontaneous preterm birth study part: -Vascular dysfunction primary outcome: difference in prevalence of hypertension and/or circulating microparticles between cases and controls -Diastolic dysfunction primary outcome: difference in the E*mean, one of the cardiac ultrasound parameters of diastolic heart function, between cases and controls.

—

Secondary

Measure	Time frame
Preeclampsia study part: The secondary outcome measure will be a difference in cardiovascular parameters and differences in metabolic venous blood measurements. Spontaneous preterm birth study part: The secondary outcome measure will be a difference in 10-year cardiovascular risk, a difference in the prevalence of metabolic syndrome, and differences in cardiovascular parameters and metabolic venous blood measurements	—

Measure

Time frame

Preeclampsia study part: The secondary outcome measure will be a difference in cardiovascular parameters and differences in metabolic venous blood measurements. Spontaneous preterm birth study part: The secondary outcome measure will be a difference in 10-year cardiovascular risk, a difference in the prevalence of metabolic syndrome, and differences in cardiovascular parameters and metabolic venous blood measurements

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Countries

Netherlands

Outcome results