Towards individual medicine in ADHD: A pilot study on using individual differences in neural reward sensitivity to predict the efficacy of a behavioral intervention in ADHD (The SCORE! study).

Towards individual medicine in ADHD: A pilot study on using individual differences in neural reward sensitivity to predict the efficacy of a behavioral intervention in ADHD (The SCORE! study). - The SCORE! study.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON45061

Enrollment

Registered

2014-04-30

Start date

2014-05-13

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ADHD Attention Deficit Hyperactivity Disorder

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria for patients (children with ADHD): 1. Age between 8;6 (8 years and 6 months) and 12;11 (12 years and 11 months). 2. A clinical diagnosis of ADHD (comorbidities are allowed in order to more closely reflect the typical clinical population), that is confirmed using the Disruptive Behavior Disorders Module (Module E) of the Diagnostic Interview Schedule for Children (DISC) (Schaffer, Fisher, Lucas, Dulcan, & Schwab-Stone, 2000).

Exclusion criteria

Exclusion criteria: 1. Estimated IQ

Design outcomes

Primary

Measure	Time frame
1. Change in the severity of ADHD symptoms as a result of treatment, measured with the well-validated Strengths and Weaknesses of ADHD and Normal behavior (SWAN) questionnaire (Lakes, Swanson, & Riggs, 2012). 2. Physiological response to reward as measured by changes in heart rate variability or skin conductance change during both reward tasks.	—

Secondary

Measure	Time frame
1. Reward sensitivity as measured by (a) the total reward sensitivity score on the SPSRQ-C, the Sensitivity to Punishment and Sensitivity to Reward Questionnaire for children; (b) Reward sensitivity index (response time distribution shift under rewarded versus non-rewarded conditions) from the child-friendly version of the Monetary Incentive Delay task and percentage of advantageous doors chosen from the Hungry Donkey Task (a child-friendly version of the Iowa Gambling Task). 2. Parental ratings of current stress related to parenting their child, as measured by the Nijmeegse Ouder Stress Index (NOSI), which is a translation of the well-validated Parenting Stress Index.	—

Measure

Time frame

1. Reward sensitivity as measured by (a) the total reward sensitivity score on the SPSRQ-C, the Sensitivity to Punishment and Sensitivity to Reward Questionnaire for children; (b) Reward sensitivity index (response time distribution shift under rewarded versus non-rewarded conditions) from the child-friendly version of the Monetary Incentive Delay task and percentage of advantageous doors chosen from the Hungry Donkey Task (a child-friendly version of the Iowa Gambling Task). 2. Parental ratings of current stress related to parenting their child, as measured by the Nijmeegse Ouder Stress Index (NOSI), which is a translation of the well-validated Parenting Stress Index.

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Countries

Netherlands

Outcome results