ulcerative colitis and inflammatory bowel disease
Conditions
Interventions
None listed
Sponsors
Maag-darm-leverziekten
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: age 18 - 60 years established diagnosis of ulcerative colitis (confirmed by clinical, endoscopic and histological features) moderate or severe disease activity (defined as a Mayo score >6 for patients with UC) indication for endoscopy (according to the Dutch CBO guidelines for diagnosis and treatment of IBD in adults) indication for induction therapy with oral prednisone (according to the Dutch CBO guidelines for diagnosis and treatment of IBD in adults) disease activity confirmed by endoscopy with at least ulcerative lesions present at baseline (ileo)colonoscopy signed informed consent
Exclusion criteria
Exclusion criteria: Concomitant gastrointestinal disorder Previous surgery for IBD Severe disease possibly requiring surgical treatment Isolated proctitis Systemic antibiotic, antiviral, or antifungal treatment during the last 2 months before participation Use of probiotics during the last 3 weeks before participation Use of antidiarrheal medications during the last week before participation Parenteral nutrition, vegetarianism, veganism, use of dietary supplements Alcohol misuse in the last year before participation (more than 3-4 units or 2-3 units per day for men and women respectively) Drug misuse in the last year before participation Pregnancy/lactation Obesity (defined as a body mass index > 30 kg/m2) Medical treatment for diabetes mellitus Serious comorbidities (precluding participation in the study in the opinion of the treating physician) Use of rectal or systemic steroid therapy, biological agents or methotrexate during the last 2 months before participation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Microbial composition of both FAM and MAM using a phylogenetic microarray (Human Intestinal Tract (HIT) Chip) and next generation sequencing. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical disease activity indices Biochemical parameters (faecal calprotectin level, C-reactive protein level, full blood count, albumin level) | — |
Countries
Netherlands
Outcome results
None listed