Effects of deoxycholic acid supplementation on insulin: role for the transmembrane G coupled protein receptor TGR5

Effects of deoxycholic acid supplementation on insulin: role for the transmembrane G coupled protein receptor TGR5 - DCA and Insulin

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON45029

Enrollment

Registered

2013-07-04

Start date

2013-09-05

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes obesity

Interventions

Addition of deoxycholate to the standard meal (1x)

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: healthy males 18+

Exclusion criteria

Exclusion criteria: Major illness in the past 3 months Gastrointestinal disease that may influence bile acid metabolism Abnormalities in ASAT / ALAT / Bilirubin / *GT / AF / fasting glucose / HbA1c laboratory data Drug abuse or alcoholism (>3 units of alcohol per day) History of cholecystectomy or other bile duct abnormalities. Strenuous exercise for at least 3 days prior to each study day, defined as more than 1 hour of exercise per day

Design outcomes

Primary

Measure	Time frame
Insulin AUC	—

Secondary

Measure	Time frame
Glucose AUC postprandial GLP-1 levels postprandial FGF19 levels	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)