patienten aan de cardiopulmonale bypass cerebral autoregulation oxygen regulation of the brain
Conditions
Interventions
Interventions pre-cardiopulmonary bypass
(1) Determination of changes in cerebral tissue oxygenation and cerebral blood
flow when both blood pressure and blood flow can vary.
In this intervention w
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - age over 18 years - undergoing cardiopulmonary bypass (CPB) for Coronary Artery Bypass Grafting (CABG) - having an appropriate temporal bone window for reliable TCD monitoring - needing pharmacological intervention because of hypotension before going on cardiopulmonary bypass.
Exclusion criteria
Exclusion criteria: - requiring hypothermia during surgery - requiring emergency surgery - having a contraindication for phenylephrine - having known brain pathology (e.g. Cerebral Vascular Accident (CVA) or increased intracranial pressure) - having a history of severe carotid artery stenosis. - having variations in hemodynamic parameters outside safe limits as described below, during the interventions * The patient has no hypotension, defined as Mean Arterial Pressure (MAP) 20% * MAP: increase > 30mmHg * Frontal lobe oxygenation (rSO2): a 20% bilateral or unilateral reduction from baseline values or an absolute decrease below 50% * pH: 7.45 * Heart rate: 80 beats per minute
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoints are the changes in the regional cerebral oxygen saturation and the mean velocity of bloodflow in the middle cerebral artery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not applicable. | — |
Countries
Netherlands
Outcome results
None listed