sarcoisosis
Conditions
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Clinical and radiologic suspicion of sarcoidose stage I (mediastinal or hilar lymphadenopathy) or stage II (lymphadenopathy and interparenchymal abnormalities); Indication for tissue verification of noncaseating granuloma*s;
Exclusion criteria
Exclusion criteria: Life expectancy less than 6 months; Obvious organ involvement of sarcoidosis with the possibility to confirm granulomas with a minimally invasive diagnostic procedure (eg skin lesion or superficial lymph node); Positive acid-fast bacilli sputum test; Contra-indication for endosonography; Under 18 years of age; Pregnancy;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The granuloma detection rate of endobronchial (EBUS) guided sampling of intrathoracic lymph nodes compared to esophageal (EUS-B using the EBUS scope) guided sampling in patients with suspected sarcoidosis stage I/II. | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity of EBUS-TBNA for diagnosing sarcoidosis; Sensitivity of EUS-B-FNA for diagnosing sarcoidosis; Granuloma detection rate of the conventional 22G needle and 25G ProCore neelde; Complications; | — |
Countries
Australia, Belgium, Canada, China, Italy, Japan, Poland, Turkey
Outcome results
None listed