disease of motor nerves inflammatory demyelinating peripheral motor neuropathy
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients are subjects who fullfil the diagnostic consensus criteria for MMN (see protocol, page 40) Controls are people who visit the neuromuscular outpatient clinic for diseases other than MMN. All subjects are older than 18 year, are not mentally incapacitated and fully understand the given information for the study
Exclusion criteria
Exclusion criteria: An MMN patient who meets any of the following criteria will be excluded from participation in this study: - Doubts about the diagnosis MMN - Relevant concomitant illnesses (i.e. haematological or immunological diseases) that may interfere with any part of the study A control will be excluded when any of the following criteria is met: - having MMN as a diagnosis in the history - under 18 years old. - not capable of understanding the given information or giving consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Natural history: Clinical disease course is determined by questionnaires and a neurological examination taken in 2007 and in the current study. Special (clinical) features is looked for in patients that have poor prognosis. Quality of life scores compared to the standardized Dutch scores. Immunological part: Anti-GM1 IgM titers and HLA haplotyping in MMN and controles -FcuR status on (subsets of) leukocytes is compared with controls. - Bacterial cultures that can express GM1 (like) epitopes is compared with controls. | — |
Countries
Netherlands
Outcome results
None listed