Risk factors for Intensive Care admission of children with severe acute wheeze or asthma

Risk factors for Intensive Care admission of children with severe acute wheeze or asthma - Status Asthmaticus on the Intensive Care Prospective - STATIC PRO

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44930

Enrollment

220

Registered

2016-04-18

Start date

2016-08-03

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

life-threatening asthma attack Status Asthmaticus

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: -Between 2 and 18 years of age -Admission to a PICU for status asthmaticus or acute wheeze -Admission to a MC for status asthmaticus or acute wheeze

Exclusion criteria

Exclusion criteria: -Patient is outside of specified age range -Patient has Down*s Syndrome -Patient has a congenital/acquired heart defect that interferes with normal SAA treatment -Patient has a congenital/acquired airway defect (Tracheomalacia, Bronchomalacia) -Patient has a primary/secondary immunodeficiency -Patient has a pre-existing chronic pulmonary condition, known to mimic asthma: Cystic fibrosis, Bronchopulmonary dysplasia, Bronchiolitis obliterans. -Any subject who receives a different diagnosis than SAA / asthma exacerbation within the timeframe of the admission -Any subject who does not provide informed consent or repeals informed consent (either by patient or by guardian(s)).

Design outcomes

Primary

Measure	Time frame
Undertreatment, defined as: Patient is not using inhaled corticosteroids (ICS), or Patient is using ICS for	—

Secondary

Measure	Time frame
* Exposure to air pollution/airborne particulate matter (PM10), acute (0,1kU/L on RAST). * Exposure to cigarette smoke, as measured by cotinine in urine. * Type of virus in upper airway tract. * Socio-economic status, defined by highest education of both parents and occupation of both parents. * Severity of asthma at follow-up, defined as 3 on GINA treatment level. A previous admission to a hospital (MC) for asthma. * A previous admission to a PICU for asthma. * Distribution of ADRB2-receptor polymorphisms, compared to the non-SAA population. * CBCL scores. The CBCL uses a continuous scale (interval) where a higher score indicates more problems within a certain area of interest. * PA(C)QLQ scores. The PAQLQ and PACQLQ use continuous scales (interval) where a higher score indicates better quality of life. * SVLK-k/o. The SVLK-k and *o use continuous scales (interval) where a higher score indicates more severe PTSD.	—

Measure

Time frame

* Exposure to air pollution/airborne particulate matter (PM10), acute (0,1kU/L on RAST). * Exposure to cigarette smoke, as measured by cotinine in urine. * Type of virus in upper airway tract. * Socio-economic status, defined by highest education of both parents and occupation of both parents. * Severity of asthma at follow-up, defined as *3 on GINA treatment level. * A previous admission to a hospital (MC) for asthma. * A previous admission to a PICU for asthma. * Distribution of ADRB2-receptor polymorphisms, compared to the non-SAA population. * CBCL scores. The CBCL uses a continuous scale (interval) where a higher score indicates more problems within a certain area of interest. * PA(C)QLQ scores. The PAQLQ and PACQLQ use continuous scales (interval) where a higher score indicates better quality of life. * SVLK-k/o. The SVLK-k and *o use continuous scales (interval) where a higher score indicates more severe PTSD.

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Countries

Netherlands

Outcome results