The bilious bowel: the relation between bile and bowel in development of biliary atresia and liver fibrosis. An explorative study

The bilious bowel: the relation between bile and bowel in development of biliary atresia and liver fibrosis. An explorative study - BiBoBa

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44888

Enrollment

Registered

2015-09-14

Start date

2015-09-03

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

liver fibrosis - scarring of the liver

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: children with hepatobiliary disease necessitating surgery

Exclusion criteria

Exclusion criteria: Adults, congenital bowel defects or abdominal wall defects, extreme prematurity/very low birth weigth

Design outcomes

Primary

Measure	Time frame
Clearance of jaundice, transplantation-free survival	—

Secondary

Measure	Time frame
Gut microbiota in faeces, serum levels of Zonulin and tight junction/translocation markers e.g. ZO-1, Claudin-1, 2 and 3, Lipopolysaccharide Binding Protein (LBP) and CD14. Secondary end points: histological assessment of both the tight junction complex in the small bowel as well as liver fibrosis as present in routine clinical pre- or preoperative liver biopsies or as assessed using Fibroscan and/or APRI	—

Measure

Time frame

Gut microbiota in faeces, serum levels of Zonulin and tight junction/translocation markers e.g. ZO-1, Claudin-1, 2 and 3, Lipopolysaccharide Binding Protein (LBP) and CD14. Secondary end points: histological assessment of both the tight junction complex in the small bowel as well as liver fibrosis as present in routine clinical pre- or preoperative liver biopsies or as assessed using Fibroscan and/or APRI

—

Countries

Netherlands

Outcome results