typische adolescenten autism high functioning autism
Conditions
Interventions
None listed
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: - Dutch Speaking - Right-handed - In the right age-range - Diagnosis in the autism spectrum - Normal of above-normal intelligence
Exclusion criteria
Exclusion criteria: - Left-handed - A psychological or neurological disorder - Current use of neurotrophic medication - Presence of chronical illness - MRI contradictions (which include metal implants, heart arrhythmia, claustrophobia, and possible pregnancy (in adult females)) - Participants will additionally be prescreened for head trauma, premature birth, learning disabilities, and history of neurological or psychiatric illness and/or use of psychotropic medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Age- and puberty related change in brain structure and function related to the construct of self-concept. MRI scans Structural MRI will be used to gain information on gray and white matter properties (volume, density, and cortical thickness). DTI will be used to gain specific information on white matter microstructure and fibertracking. Functional MRI will be used to gain information on task-related brain activity during cognitive and emotional information processing. Pubertal assessment Participant will fill in a self-report form of pubertal maturation. Second the participants will provide saliva to test for testosterone, DHEA, and estradiol levels. Addendum Gap Year: This study is focused on studying the changes in behavioral measures and brain function and structure related to the selfconcept training of the Gap Year Program. Behavioral measures: Tasks and questionnaires focused on diverse aspects of self-concept. For example, self-knowledge, self-esteem and self-concept clarity. See for more information section 8.3 "study procedures" of the protocol. MRI scans: Structural MRI will be used to gain information on gray and white matter properties (volume, density, and cortical thickness). DTI will be used to gain specific information on white matter micro-structure and fiber tracking. Functional MRI will be used to gain information on task-related brain activity during cognitive and emotional information processing. Addendum ASD: Addendum Gap Year: This study is focused on studying the changes in behavioral measures and brain function and structure related to the selfconcept training of the Gap Year Program. Behavioral measures: Tasks and questionnaires focused on diverse aspects of self-concept. For example, self-knowledge, self-esteem and self-concept clarity. See for more information section 8.3 "study procedures" of the protocol. MRI scans: Structural MRI will be used to gain information on gray and white matter properties | — |
Secondary
| Measure | Time frame |
|---|---|
| see above. | — |
Countries
Netherlands