Coeliac sprue Gluten intolerance
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: All children that undergo diagnostic upper gastrointestinal endoscopy under general anesthesia for medical reasons in the Willem-Alexander Children*s Hospital of the LUMC are eligible for the study. Around 120 children undergo upper gastrointestinal endoscopy in the Department of Pediatrics of the LUMC each year. They will be divided in - Cases: all children that are diagnosed with coeliac disease according to accepted criteria - Controls: all children that are diagnosed with other conditions unrelated to coeliac disease ;Informed consent and suffiecient knowledge / understanding of the Dutch language are mandatory
Exclusion criteria
Exclusion criteria: - No informed consent - Insufficient knowledge / understanding of Dutch language - Prior participation in protocol P06.140 or the present study if subject has undergone more than one endoscopy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Definition of the disease associated T cell receptor repertoire in a large group of paediatric patients. Determination of the functional characteristics of the disease associated T cells. Correlation of the disease associated T cell receptor repertoire with disease onset and/or severity Phenotypic and functional characterisation of the intraepithelial lymphocyte compartment in patients with and without CD. Analysis of the cytokine mediated crosstalk between the lamina propria and epithelial compartments. | — |
Secondary
| Measure | Time frame |
|---|---|
| Ultimately we aim to develop novel diagnostics and preventive and therapeutic approaches for CD. | — |
Countries
Netherlands
Outcome results
None listed