Prevalence of gastrointestinal disorders in the general population 50 to 75 years in the Ommoord municipality: videocapsule in the Rotterdam study

Prevalence of gastrointestinal disorders in the general population 50 to 75 years in the Ommoord municipality: videocapsule in the Rotterdam study - Videocapsule-ERGO

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44830

Enrollment

1000

Registered

2016-04-28

Start date

2017-10-02

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

celiac disease polyps ulcers

Interventions

Participants are invited to videocapsule endoscopy (VCE) screening using the Pillcam colon 2L (Given Imaging ltd. Israel). Colon cleansing consists of a Senna tablet (Sennocol 185 mg

Meda Pharma BV, Amstelveen, The Netherlands) at bedtime 2 days before CCE. Subsequently all participants will start a liquid diet at 13:00 the day before VCE and will receive 2 liter of polyethylene

Norgine, Amsterdam, The Netherlands) and 2 liter transparent fluid, split-dose. Booster during VCE procedure consists of additional 250ml Eziclen boost and an optional 250ml Eziclen boost, each fol

it will take 5-10 minutes to complete one questionnaire. Participants are asked to perform a stool test (FIT)

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - 50-74 years - participant Rotterdam study

Exclusion criteria

Exclusion criteria: - Inability or refusal to provide informed consent. - Persons with a severe or terminal disease with a life-expectancy of less than 5 years. - An allergy or any other known contraindication to the medication used in this study - Renal failure, eGFR

Design outcomes

Primary

Measure	Time frame
Prevalence of: - Inflammation, ulcerations and erosions of the gastrointestinal tract, including peptic ulcers - Barrets esophagus - Celiac disease - Gastrointestinal bleeding - Small bowel polyps - Large bowel polyps	—

Secondary

Measure	Time frame
In this study, the entire digestive tract imaged. As a result, the research provides information about the entire gastro-intestinal tract. These images are relevant and of great value because they reveal information about prevalence of diseases in the general asymptomatic population. ERGO hereby provides the unique ability to relate this information to factors such as drug use, medical history, and other determinants. In addition, the findings are compared with the findings at endoscopy if subjects are referred for endoscopy. Recently, an association was made between the microbiome and microRNA (miRNA) and carcinogenesis. The gut microbiome consists of 100 trillion micro-organisms in the gut and has an important immune, structural, metabolic and defence function in the gut. MiRNAs are small non-coding regulatory RNAs with sizes of 20-24 nucleotides. Their function in the human genome consists of the regulation of gene expression. Both microbiome and miRNA could be involved in the carcinogenesis. To further explore the involvement in carcinogenesis, it is necessary to know the composition of the microbiome and miRNA in healthy individuals.	—

Measure

Time frame

In this study, the entire digestive tract imaged. As a result, the research provides information about the entire gastro-intestinal tract. These images are relevant and of great value because they reveal information about prevalence of diseases in the general asymptomatic population. ERGO hereby provides the unique ability to relate this information to factors such as drug use, medical history, and other determinants. In addition, the findings are compared with the findings at endoscopy if subjects are referred for endoscopy. Recently, an association was made between the microbiome and microRNA (miRNA) and carcinogenesis. The gut microbiome consists of 100 trillion micro-organisms in the gut and has an important immune, structural, metabolic and defence function in the gut. MiRNAs are small non-coding regulatory RNAs with sizes of 20-24 nucleotides. Their function in the human genome consists of the regulation of gene expression. Both microbiome and miRNA could be involved in the carcinogenesis. To further explore the involvement in carcinogenesis, it is necessary to know the composition of the microbiome and miRNA in healthy individuals.

—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)