Obstructive sleep apnea sydrome (OSAS) sleep-disordered breathing (SDB)
Conditions
Interventions
The SPT trains POSA patients to sleep in non-supine positions, CPAP uses
positive airway pressure to open the airway
MRA is an intra-oral prosthesis,
which holds the mandible in a protrusive position, all to prevent effectively
apneic events.
Continuous positive airway pressure
Cost-effectiveness
Mandibular advancement device
Sponsors
Onze Lieve Vrouwe Gasthuis
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Diagnosis with symptomatic mild or moderate OSA (15 as high as AHI non-supine.
Exclusion criteria
Exclusion criteria: - Many dental problems; insufficient teeth for wearing MRA - Medication used/ related to sleeping disorders - Central Sleep Apnea Syndrome. - Night or shifting work. - Severe chronic heart failure, - Medical history of known causes of tiredness by day or severe sleep disruption (insomnia, PLMS, Narcolepsy). - Seizure disorder. - Known medical history of mental retardation, memory disorders or psychiatric disorders. - Shoulder, neck and back complaints. - Reversible morphological upper airway abnormalities (e.g. enlarged tonsils), - Inability to provide informed consent. - Simultaneous use of other treatment modalities to treat OSA. - Previous treatment for OSA with MRA, CPAP or SPT - Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| primary ouctome: AHI | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Outcome of Quality of Life questionnaires; EQ-5D, ESS and FOSQ. 2) (Societal) costs of treatment; Healthcare Consumption, Illness and Work (HCIW) questionnaire (PCQ/MCQ, successors of TiC-P and PRODISQ). 3) Compliance, i.e. more than 4 hours of usage per night. 4) Cardiovascular parameters: blood pressure, pulse rate, BMI and neck circumference | — |
Countries
Belgium, Netherlands
Outcome results
None listed