Migraine
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age between 40 and 60 years Female Capable and willing to provide informed consent Stroke cohorts: stroke diagnosed by cerebral imaging and verified in clinical records Preeclampsia cohorts: fulfil criteria for diagnosis PE, verified in clinical records PCOS cohorts: fulfil Rotterdam criteria for diagnosis PCOS
Exclusion criteria
Exclusion criteria: Insufficient mastery of Dutch Any serious illness that can compromise study participation Current pregnancy Stroke cohorts: TIA, retinal infarction or venous infarction Contra-indications for MRI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| * White matter hyperintensities (WMH) load on brain Magnetic Resonance Imaging (MRI) graded in volume. * Endothelial function measured as dermal blood flow changes (DBF) after Local Thermal Hyperaemia (LTH) using Laser Doppler Perfusion imaging (LDPI) expressed in arbitrary units. * Endothelial function measured as Reactive Hyperaemia Index (RHI) using Peripheral Arterial Tonometry (EndoPAT) expressed in arbitrary units. | — |
Secondary
| Measure | Time frame |
|---|---|
| * Location of white matter hyperintensities * Location of stroke * Stroke subtype (large artery, cardioembolism, small vessel occlusion, other determined, undetermined) * Comparison of LTH measurements after pre-treatment with EMLA or LNMMA * Serum markers for endothelial dysfunction and gonadal hormone levels | — |
Countries
Netherlands
Outcome results
None listed