Idiographic study of Cognitive function, Affect, and Sleep in the Elderly

Idiographic study of Cognitive function, Affect, and Sleep in the Elderly - i-CASE

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44788

Enrollment

Registered

2013-12-03

Start date

2016-01-12

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dementie en amnestische stoornissen (onder psychische stoornissen) affect depression memory problems mood

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age 60 or above - informed consent given by patient - cognitive deficits according to memory clinic or MMSE3

Exclusion criteria

Exclusion criteria: - severe medical illness known to influence short-term survival;- Moderate and severe dementia (indicated by Clinical Dementia Rating Scale 2 or 3) - neurological disorders (other than MCI or dementia as defined in the inclusion criteria);- presence of the following mental health disorders in the past 2 years: bipolar disorder, psychotic disorders, severe substance use disorders;- incapable of participation in study procedures (i.e. non-Dutch language, incapable of filling in the diaries, no internet connection at home);- mentally incompetent to give consent for study participation according to judgement of treating specialist;- Incapable to participate in study as it shows from the 3-day practice period (for example not being capable of using the ipad, intolerance to actiwatch, forgetting assessments)

Design outcomes

Primary

Measure	Time frame
Temporal patterns of depressive symptoms, cognitive function and sleep disturbances. Unique to time-series analyses all three variables can be both determinant and outcome (which may differ between patients, see analyses).	—

Secondary

Measure	Time frame
See also the document: "overzicht metingen". Inclusion interview: - Presence of DSM-IV diagnosis of depression (MINI) - Severity of depressive symptoms (GDS-15) - Cognitive screen: MOCA Patient characteristics at baseline, from baseline questionaire: - Demographic variables (age, sex, living situation, marital status, education level, work) - Smoking - Somatic diseases - Treatments for depression and/or sleep disturbances - Presence and severity of sleep disturbances (PSQI) - Chronotype (MCTQ) - Restless legs syndrome - Sleep apnea - Medication use (assessed by researcher during baseline assessment) Patient characteristics from medical files: - Results of diagnostic tests to evaluate the likelihood of Alzheimer's disease (among which, MRI, PET, lumbar punction) - Results of neuropsychological examination to evaluate the degree of cognitive impairments Daily measured variables used in time-series analyses to evaluate their influence on the temporal patterns of depression, sleep disturbances and cognitive functioning: - Parameters of circadian rhythm and objective sleep disturbances assessed with actiwatch - Subjective memory impairments, assessed in electronic diary - Use of sleeping pills, assessed in electronic diary - Physical activity, assessed in electronic diary - Daily use of alcohol, cafeine and cigarettes, assessed in electronic diary, - Pain, assessed in electronic diary - Important events, assessed in electronic diary Weekly evaluated by researchter during telephone interview: - Changes in (any) medications - Changes in therapies for depression or sleep disturbances - Important events End of study period questionnaire: - Experiences of participant with the study/data collection Two months after end of study (= 4 months after start of study) - Insight questionnaire asking patient whether he or she gained more insight into the causes of his/her depressive complaints and/or sleep problems and/or cognitive complaints T	—

Measure

Time frame

See also the document: "overzicht metingen". Inclusion interview: - Presence of DSM-IV diagnosis of depression (MINI) - Severity of depressive symptoms (GDS-15) - Cognitive screen: MOCA Patient characteristics at baseline, from baseline questionaire: - Demographic variables (age, sex, living situation, marital status, education level, work) - Smoking - Somatic diseases - Treatments for depression and/or sleep disturbances - Presence and severity of sleep disturbances (PSQI) - Chronotype (MCTQ) - Restless legs syndrome - Sleep apnea - Medication use (assessed by researcher during baseline assessment) Patient characteristics from medical files: - Results of diagnostic tests to evaluate the likelihood of Alzheimer's disease (among which, MRI, PET, lumbar punction) - Results of neuropsychological examination to evaluate the degree of cognitive impairments Daily measured variables used in time-series analyses to evaluate their influence on the temporal patterns of depression, sleep disturbances and cognitive functioning: - Parameters of circadian rhythm and objective sleep disturbances assessed with actiwatch - Subjective memory impairments, assessed in electronic diary - Use of sleeping pills, assessed in electronic diary - Physical activity, assessed in electronic diary - Daily use of alcohol, cafeine and cigarettes, assessed in electronic diary, - Pain, assessed in electronic diary - Important events, assessed in electronic diary Weekly evaluated by researchter during telephone interview: - Changes in (any) medications - Changes in therapies for depression or sleep disturbances - Important events End of study period questionnaire: - Experiences of participant with the study/data collection Two months after end of study (= 4 months after start of study) - Insight questionnaire asking patient whether he or she gained more insight into the causes of his/her depressive complaints and/or sleep problems and/or cognitive complaints T

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Countries

Netherlands

Outcome results