hypertrophy thickening of the heart muscle
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: HOCM-patients scheduled for classic myectomy and eligible for CMR-and PET imaging. Indication for myectomy was based on a significant LV outflow tract (LVOT) pressure gradient >=30 mmHg at rest or provoked as documented by echocardiography and symptoms, despite optimal medical treatment. Aortic valve stenosis patients selected to undergo valve surgery, according to the ESC-guidelines on the management of valvular heart disease. Non-hypertrophic carriers (NHC) eligible for CMR- and PET imaging;Ref. Vahanian A et al. Guidelines on the management of valvular heart disease: The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology. Eur Heart J. 2007 Jan;28(2):230-68. ;Protocol page 11-12
Exclusion criteria
Exclusion criteria: Any absolute or relative contra-indication for CMR imaging (i.e. pacemaker and claustrophobia) or failure to give informed consent. Severely impaired renal function with a glomerular filtration rate (GFR)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation of energetic properties of the HOCM-heart (in vivo assessment with PET and MRI) with it*s in vitro (myofilamental) efficiency of contraction. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Comparison of energymetabolism (in vivo, in vitro) between HCM, aortic valve stenosis and non-hypertrophic carriers. - Histological determination of interstitial fibrosis and it*s relation to septal (regional) contraction using CMR tagging. - Peak strain values compared to contractile velocities of myofilaments. - Relation between existence of myocardial disarray and the extent of remodelling. | — |
Countries
Netherlands
Outcome results
None listed