Neurobiology and Treatment of Adolescent Female Conduct Disorder: The Central Role of Emotion Processing.

Neurobiology and Treatment of Adolescent Female Conduct Disorder: The Central Role of Emotion Processing. - FemNAT-CD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44782

Enrollment

180

Registered

2014-08-25

Start date

2014-08-20

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

antisocial behaviour behavioural problems

Interventions

To date, treatment programs are not widely implemented and evaluated in middle childhood and adolescence, although adolescence is one of the key periods for intervening, most notably in CD girls due

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age: 9-18 years old - normal or corrected to normal vision and hearing - good level of Dutch reading and listening - Diagnostic criteria for CASES: current diagnosis of Conduct Disorder (CD) OR diagnosis of CD in the past, while currently 'only' two symptoms of Oppositional Defiant Disorder (ODD) are present in combination with one CD symptom. OR: - 9-12 year olds: Diagnosis of ODD + (at least) one symptom of CD - 13-18 year olds: Diagnosis of ODD + (at least) two symptoms of CD;- Diagnostic criteria for controls: no current psychiatric disorder and no history of ADHD, ODD, CD

Exclusion criteria

Exclusion criteria: - formal clinical diagnosis of an autism spectrum disorder or a neurodevelopmental syndrome - IQ 1 hour) or confirmed traumatic brain injury - severe epilepsy - exclusion criterion for the control group: any Axis I disorder, or diagnosis of CD, ODD, ADHD in the past

Design outcomes

Primary

Measure	Time frame
• Autonomic Nervous System activity: heart rate, heart rate variability, respiratory sinus arrhythmia, pre-ejection period, and skin conductance level in rest and during reactivity to emotionally arousing stimuli • Neuroendocrinology: basal levels of cortisol, testosterone, dehydroepiandrosterone sulfate (DHEA-S), alpha-amylase, progesterone, estradiol, oxytocin, and Vasopressin (AVP). And reactivity to a social stressor of cortisol and testosterone.	—

Measure

Time frame

• Autonomic Nervous System activity: heart rate, heart rate variability, respiratory sinus arrhythmia, pre-ejection period, and skin conductance level in rest and during reactivity to emotionally arousing stimuli • Neuroendocrinology: basal levels of cortisol, testosterone, dehydroepiandrosterone sulfate (DHEA-S), alpha-amylase, progesterone, estradiol, oxytocin, and Vasopressin (AVP). And reactivity to a social stressor of cortisol and testosterone.

—

Secondary

Measure	Time frame
• Psychiatric disorders • Psychopathic traits • Intelligence • Reactive and proactive aggression • Parenting behavior • Emotion Regulation • Empathy • Pubertal development • Callous-Unemotional traits • Socio-demographic factors • Medication and drug use • Brain structure and functioning	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)