Cognitive Decline in Older Patients with End stage Renal Disease

Cognitive Decline in Older Patients with End stage Renal Disease - COPE

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44778

Enrollment

250

Registered

2014-03-12

Start date

2014-04-08

Completion date

Unknown

Last updated

2024-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney Failure

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: > 65 years of age with eGFR

Exclusion criteria

Exclusion criteria: Illiterat foreign language Unable to give informed consent

Design outcomes

Primary

Measure	Time frame
Our primary analysis will be to calculate the mean change in MMSE score and cognitive test battery (Stroop, Letter Digit Coding Test and Picture Learning, Immediate and Delayed) after initiation of RRT. To determine whether this change in cognitive function is attributable to the initiation of RRT, we will compare these change to 1) change in MMSE score and cognitive and functional test battery in those older patients who did not initiate RRT in two consecutive years (n=200), 2) change in MMSE score and cognitive and functional test battery in the individuals who did initiate RRT in two consecutive years prior to start of RRT. 3) the association between the change in MMSE score and cognitive and functional test battery after initiation of RRT with various parameters of brain structure (measures of vascular cognitive impairment) or perfusion (measures of auto-regulation) at baseline.	—

Measure

Time frame

Our primary analysis will be to calculate the mean change in MMSE score and cognitive test battery (Stroop, Letter Digit Coding Test and Picture Learning, Immediate and Delayed) after initiation of RRT. To determine whether this change in cognitive function is attributable to the initiation of RRT, we will compare these change to 1) change in MMSE score and cognitive and functional test battery in those older patients who did not initiate RRT in two consecutive years (n=200), 2) change in MMSE score and cognitive and functional test battery in the individuals who did initiate RRT in two consecutive years prior to start of RRT. 3) the association between the change in MMSE score and cognitive and functional test battery after initiation of RRT with various parameters of brain structure (measures of vascular cognitive impairment) or perfusion (measures of auto-regulation) at baseline.

—

Secondary

Measure	Time frame
Our secondary analysis will be: 1) to evaluate the correlation between the results of CGA and cognitive test battery and cardiovascular markers and disease, metabolic parameters, and (the rate of decline) of eGFR. 2) Correlation between outcome of CGA and the impact of disease on quality of life.	—

Countries

Netherlands

Outcome results