Prevention of breast cancer in high risk women by monitoring microrna expression in nipple aspirate fluid.

Prevention of breast cancer in high risk women by monitoring microrna expression in nipple aspirate fluid. - MicroRNA expression in nipple aspirate fluid.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44762

Enrollment

720

Registered

2006-06-06

Start date

2008-08-07

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

breast cancer breast carcinoma

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Germline BRCA1 or BRCA2 mutation - A > 20% lifetime risk of developing breast cancer - Previous DCIS/invasive breast cancer

Exclusion criteria

Exclusion criteria: -Bilateral ablative breast surgery -Bilateral breast reduction with nipple graft -Pregnancy or lactating -Active breast infection -Disseminated disease

Design outcomes

Primary

Measure	Time frame
-Quantification of miRNA expression levels from nipple aspirate fluid samples collected annually. -Breast cancer development and their histological features. -Establishing a biobank of blood samples (plasma and serum) of women at increased breast cancer risk	—

Secondary

Measure	Time frame
-Discomfort, uncertainty and distress experienced because of and during procedure	—

Countries

Netherlands

Outcome results