myocardial infarction
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Subject is diagnosed with acute myocardial infarction. Subject is 18 years or older.
Exclusion criteria
Exclusion criteria: Subject with known prior acute myocardial infarction, cardiac surgery, or valvular diseases. Subject is implanted with MRI incompatible prostheses or devices. Subject has an indication for implantable cardio defibrillator. Subject is in a condition that alters the collagen turnover. Subject underwent recent trauma or surgery in the last 6 months. Subject is diagnosed with kidney failure. Subject is known with an allergy against gadolinium-based contrast agents. Subject is familiar with claustrophobia. Subject is pregnant or has given birth within the past 90 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Cardiac fibrosis determined by contrast MRI at 4-6 months after myocardial infarction. - Circulating biomarkers (related to fibrosis) at 4-6 months after myocardial infarction. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Circulating biomarkers (related to fibrosis) at other time points. - New circulating biomarkers (related to fibrosis and cardiac function) - Cardiac function - Death - Composite endpoint of non-fatal myocardial infarction, stroke, cardiovascular hospitalisation or cardiovascular death. - Heart failure - Fibrosis determined with new MRI techniques | — |
Countries
Netherlands
Outcome results
None listed